FUCA1

Across TCGA cell cohorts, FUCA1 mutation is significantly associated with the RNA expression of many other genes, with 7 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible FUCA1-associated genes across cancer lineages are RIT2, PABPC1L2A, and TFAP2D. Each is linked with FUCA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FUCA1-to-partner and partner-to-FUCA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RIT2 grouped by FUCA1-low versus FUCA1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FUCA1→partner) and Y-score (partner→FUCA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	RIT2 →	+0.040	+6.022	<.001	.001	3	1
SKIN	PABPC1L2A →	+0.047	+4.977	<.001	.007	3	1
SKIN	TFAP2D →	+0.154	+5.415	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR4F5 →	+0.019	+4.887	<.001	.009	3	1
BLOOD_Leukemia	TAAR8 →	+0.009	+3.969	<.001	.009	3	1
BLOOD_Leukemia	MBD3L5 →	+0.018	+4.569	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

RIT2 by FUCA1 expression — SKIN

Explore this box plot interactively →