Q-omics provides the consensus-scored FTOP1 profile across patient tissues and cancer cell-line models. FTOP1 expression is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, FTOP1 is differentially expressed in 12, with the highest sampling consensus in THCA. Additionally, FTOP1 RNA expression shows 19,181 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight HNSC, THCA, and THYM as cancer lineages where FTOP1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for FTOP1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes FTOP1 survival associations across molecular data types. FTOP1 RNA expression shows survival associations in the most cancer types (19). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible FTOP1 RNA expression–survival associations across cancer types. High FTOP1 expression shows unfavorable associations in ACC, but favorable associations in HNSC, KIRP, READ, UCS and CESC. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p = .001). Together, the overview and detailed table identify HNSC as the clearest survival context for FTOP1 RNA expression.
This table summarizes FTOP1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for FTOP1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. FTOP1 shows lower tumor expression in THCA, UCEC, BRCA, BLCA and CHOL and higher tumor expression in KIRC. The THCA box plot shows higher FTOP1 RNA expression in normal versus tumor tissue (log2 FC = −0.651, t-test p < 0.001).
This table shows molecular features associated with FTOP1 in patient tissues and cancer cell lines. In patient samples, FTOP1 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set.
