FTO

Across TCGA pan-cancer cohorts, FTO mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated FTO data layer compared with 21 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher FTO mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FTO expression acts as an unfavorable survival marker, although some lineages such as LUAD and GBM show a favorable association.

COAD, UCEC, and LSCC are the cancer types where FTO mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	IV	0.493	0.944	.031	24	view →
UCEC	OS	Quartile	II,III,IV	0.327	1.000	.005	20	view →
LSCC	OS	Median	All	0.797	0.938	.009	16	view →
LUAD	OS	Median	II,III,IV	1.000	0.339	<.001	15	view →
GBM	DFS	Tertile	All	0.406	0.241	.014	13	view →
CCRCC	DFS	Tertile	All	1.000	0.686	.030	13	view →
PDAC	DFS	Median	All	0.812	0.712	.015	4	view →
HNSC	DFS	Tertile	IV	0.498	0.734	.045	1	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

FTO–COAD (DFS)

Open the COAD breakdown →