FTO

Across TCGA patient cohorts, FTO RNA expression is significantly associated with the protein abundance of many other proteins, with 15,640 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible FTO-associated proteins across cancer lineages are NUBP1_S312, MAP1A, and SLC38A1_S52. Each is linked with FTO in more than 4 cancer types. Because this analysis shows association rather than direction, both FTO-to-partner and partner-to-FTO results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FTO versus NUBP1_S312 in BRCA, with a Pearson correlation of 0.29.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (FTO→partner) and Y-score (partner→FTO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	NUBP1_S312 →	+0.696	+0.738	.001	<.001	3	5
HNSC	MAP1A →	+0.505	+0.442	<.001	<.001	3	5
LSCC	SLC38A1_S52 →	-0.652	-0.273	<.001	<.001	3	5
OV	FLNA →	+0.500	+0.756	.002	.001	3	5
OV	RAI14 →	+0.376	+0.701	.001	.001	3	5
GBM	ARL2BP →	+0.296	+0.394	.008	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,640 associations by consensus.

FTO vs NUBP1_S312 — BRCA

Explore this scatter interactively →