FTO

Across TCGA patient cohorts, FTO protein abundance is significantly associated with the RNA expression of many other genes, with 13,127 significant associations in total. GBM shows the largest number of these associations.

The most reproducible FTO-associated genes across cancer lineages are PRMT7, AKTIP, and ZNF821. Each is linked with FTO in more than 6 cancer types. Because this analysis shows association rather than direction, both FTO-to-partner and partner-to-FTO results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FTO versus PRMT7 in HNSC, with a Pearson correlation of 0.43.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FTO→partner) and Y-score (partner→FTO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	PRMT7 →	+0.551	+0.327	<.001	<.001	3	7
BRCA	AKTIP →	+0.471	+0.256	<.001	<.001	3	7
OV	ZNF821 →	+0.454	+0.316	.004	.004	3	6
OV	TANGO6 →	+0.623	+0.308	.002	.003	3	6
LUAD	ENKD1 →	+0.608	+0.224	.001	.002	3	6
LSCC	ZCCHC14 →	+0.587	+0.261	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,127 associations by consensus.

FTO vs PRMT7 — HNSC

Explore this scatter interactively →