FTO

Across TCGA patient cohorts, FTO mutation is significantly associated with the RNA expression of many other genes, with 1,962 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FTO-associated genes across cancer lineages are PHF5A, CMC2, and BNIP1. Each is linked with FTO in more than 2 cancer types. Because this analysis shows association rather than direction, both FTO-to-partner and partner-to-FTO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PHF5A grouped by FTO-low versus FTO-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FTO→partner) and Y-score (partner→FTO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PHF5A →	+0.657	+4.247	<.001	<.001	3	2
UCEC	CMC2 →	+0.566	+3.065	<.001	<.001	3	2
UCEC	BNIP1 →	+0.413	+3.169	<.001	<.001	3	2
COAD	TIMM17A →	+0.461	+3.459	.002	.005	3	2
COAD	ACVR1B →	-0.710	-3.392	<.001	.005	3	2
UCEC	APTX →	+0.334	+3.483	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,962 associations by consensus.

PHF5A by FTO expression — UCEC

Explore this box plot interactively →