FTO

Across TCGA patient cohorts, FTO mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FTO-associated genes across cancer lineages are HSP70, INPP4B, and ATM. Each is linked with FTO in more than 1 cancer types. Because this analysis shows association rather than direction, both FTO-to-partner and partner-to-FTO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HSP70 grouped by FTO-low versus FTO-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FTO→partner) and Y-score (partner→FTO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HSP70 →	-0.385	-2.990	.039	.036	3	2
UCEC	INPP4B →	-0.305	-2.584	.043	.010	3	2
UCEC	ATM →	-0.716	-3.308	<.001	.009	3	2
UCEC	14-3-3_beta →	-0.105	-2.973	.024	.035	3	1
UCEC	eEF2 →	+0.572	+3.700	<.001	.001	2	2
UCEC	EGFR_pY1068 →	-0.368	-3.321	.001	.010	2	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

HSP70 by FTO expression — UCEC

Explore this box plot interactively →