FTO

Across TCGA cell cohorts, FTO RNA expression is significantly associated with the go_rna of many other GO terms, with 4,919 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FTO-associated GO terms across cancer lineages are Regulation of white fat cell proliferation, Nucleic acid transport, and RNA transport. Each is linked with FTO in more than 13 cancer types. Because this analysis shows association rather than direction, both FTO-to-partner and partner-to-FTO results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of white fat cell proliferation grouped by FTO-low versus FTO-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FTO→partner) and Y-score (partner→FTO) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	Regulation of white fat cell proliferation →	+0.346	+1.054	.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Nucleic acid transport →	+0.106	+1.074	.001	.002	3	13
UPPER_AERODIGESTIVE_TRACT	RNA transport →	+0.106	+1.074	.001	.002	3	13
STOMACH	Establishment of RNA localization →	+0.104	+1.175	<.001	.002	3	13
STOMACH	RNA localization →	+0.111	+1.144	<.001	.002	3	13
STOMACH	Protein localization to nucleus →	+0.064	+1.050	.001	.006	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,919 associations by consensus.

Regulation of white fat cell proliferation by FTO expression — PANCREAS

Explore this box plot interactively →