FTL

Across TCGA pan-cancer cohorts, FTL mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated FTL data layer compared with 23 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher FTL mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FTL expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

COAD, PDAC, and UCEC are the cancer types where FTL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	II,III,IV	0.810	1.000	.010	78	view →
PDAC	DFS	Median	II,III,IV	0.677	0.872	.002	29	view →
UCEC	DFS	Tertile	II,III,IV	0.520	1.000	.008	12	view →
LUAD	OS	Median	II,III,IV	0.296	0.857	<.001	11	view →
HNSC	DFS	Median	All	0.562	0.743	.020	10	view →
CCRCC	DFS	Median	All	0.855	0.629	.004	7	view →
GBM	OS	Quartile	All	0.404	0.680	.010	5	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

FTL–COAD (DFS)

Open the COAD breakdown →