FTL

Across TCGA patient cohorts, FTL mutation is significantly associated with the RNA expression of many other genes, with 92 significant associations in total. CESC shows the largest number of these associations.

The most reproducible FTL-associated genes across cancer lineages are RNU4-88P, LYZL1, and TRIM51. Each is linked with FTL in more than 1 cancer types. Because this analysis shows association rather than direction, both FTL-to-partner and partner-to-FTL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-88P grouped by FTL-low versus FTL-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FTL→partner) and Y-score (partner→FTL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	RNU4-88P →	+0.348	+7.640	<.001	.009	3	2
CESC	LYZL1 →	+0.056	+5.418	<.001	.005	3	1
CESC	TRIM51 →	+0.852	+5.010	<.001	.009	3	1
CESC	NPBWR2 →	+0.056	+5.010	<.001	.009	3	1
CESC	TRIM53BP →	+0.312	+5.418	<.001	.005	3	1
CESC	KRTAP4-4 →	+0.203	+5.201	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 92 associations by consensus.

RNU4-88P by FTL expression — BLCA

Explore this box plot interactively →