FTHL17

Across TCGA patient cohorts, FTHL17 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FTHL17-associated genes across cancer lineages are p62 Lck ligand, EGFR_pY1068, and Lck. Each is linked with FTHL17 in more than 1 cancer types. Because this analysis shows association rather than direction, both FTHL17-to-partner and partner-to-FTHL17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by FTHL17-low versus FTHL17-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FTHL17→partner) and Y-score (partner→FTHL17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.297	+2.321	.027	.006	3	2
UCEC	EGFR_pY1068 →	-0.218	-1.807	.035	.027	3	1
UCEC	Lck →	+0.181	+1.807	.029	.027	3	1
UCEC	MEK1 →	+0.443	+2.584	.003	.010	3	1
UCEC	p38-MAPK →	+0.176	+2.820	.009	.035	3	1
UCEC	PDK1_pS241 →	+0.236	+2.700	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

p62 Lck ligand by FTHL17 expression — UCEC

Explore this box plot interactively →