FTHL17

Across TCGA cell cohorts, FTHL17 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FTHL17-associated genes across cancer lineages are HRG, KLRD1, and ODF1. Each is linked with FTHL17 in more than 1 cancer types. Because this analysis shows association rather than direction, both FTHL17-to-partner and partner-to-FTHL17 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HRG grouped by FTHL17-low versus FTHL17-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FTHL17→partner) and Y-score (partner→FTHL17) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	HRG →	+0.349	+3.855	<.001	.007	3	1
BLOOD_Leukemia	KLRD1 →	+0.262	+3.769	<.001	.008	3	1
BLOOD_Leukemia	ODF1 →	+0.097	+3.944	<.001	.006	3	1
BLOOD_Leukemia	ZIC3 →	+0.015	+4.060	<.001	.003	3	1
BLOOD_Leukemia	CYP4A11 →	+0.025	+3.705	<.001	.007	3	1
BLOOD_Leukemia	IL1RAPL2 →	+0.259	+4.037	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

HRG by FTHL17 expression — BLOOD_Leukemia

Explore this box plot interactively →