Across TCGA pan-cancer cohorts, FTH1P6 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of FTH1P6’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where FTH1P6 RNA is repressed in tumor relative to normal tissue. In most cancer types FTH1P6 is over-expressed in tumor, although a few such as BRCA show the opposite, repressed pattern.
BRCA are the cancer types where FTH1P6 tumor–normal differential expression is most reproducible.