FTH1

Across TCGA pan-cancer cohorts, FTH1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FTH1 data layer compared with 26 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher FTH1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FTH1 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

COAD, PDAC, and LUAD are the cancer types where FTH1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Quartile	II,III,IV	0.749	1.000	.010	72	view →
PDAC	DFS	Quartile	All	0.283	0.537	<.001	67	view →
LUAD	OS	Tertile	All	0.874	1.000	.008	17	view →
OV	DFS	Quartile	All	0.533	1.000	.043	4	view →
LSCC	DFS	Median	All	0.988	0.890	.022	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FTH1–COAD (DFS)

Open the COAD breakdown →