FTH1

Across TCGA cell cohorts, FTH1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,707 significant associations in total. BONE shows the largest number of these associations.

The most reproducible FTH1-associated GO terms across cancer lineages are Response to thyroxine, Cellular response to chemical stress, and Regulation of cytokine-mediated signaling pathway. Each is linked with FTH1 in more than 9 cancer types. Because this analysis shows association rather than direction, both FTH1-to-partner and partner-to-FTH1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Response to thyroxine grouped by FTH1-low versus FTH1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FTH1→partner) and Y-score (partner→FTH1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Response to thyroxine →	+0.194	+1.067	<.001	<.001	3	10
BONE	Cellular response to chemical stress →	+0.051	+1.573	.002	<.001	3	10
OVARY	Regulation of cytokine-mediated signaling pathway →	+0.063	+1.739	.001	<.001	3	9
BONE	Regulation of extrinsic apoptotic signaling pathway →	+0.079	+1.345	.009	.004	3	9
LUNG_SCLC	Cellular response to jasmonic acid stimulus →	+1.510	+0.938	<.001	.001	3	9
BONE	Low-density lipoprotein particle clearance →	+0.132	+1.260	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,707 associations by consensus.

Response to thyroxine by FTH1 expression — LIVER

Explore this box plot interactively →