FTCD

Across TCGA patient cohorts, FTCD mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FTCD-associated genes across cancer lineages are 4E-BP1, Cyclin-B1, and 14-3-3_beta. Each is linked with FTCD in more than 2 cancer types. Because this analysis shows association rather than direction, both FTCD-to-partner and partner-to-FTCD results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by FTCD-low versus FTCD-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FTCD→partner) and Y-score (partner→FTCD) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.210	+1.904	.035	.029	3	3
UCEC	Cyclin-B1 →	+0.644	+1.847	.001	.008	3	2
UCEC	14-3-3_beta →	-0.135	-3.780	<.001	<.001	3	1
UCEC	ERK2 →	+0.162	+2.000	.021	.030	3	1
UCEC	Fibronectin →	-0.272	-2.212	.024	.010	3	1
UCEC	GATA6 →	-0.142	-1.700	.016	.042	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

4E-BP1 by FTCD expression — UCEC

Explore this box plot interactively →