FSTL4

Across TCGA patient cohorts, FSTL4 mutation is significantly associated with the RNA expression of many other genes, with 5,938 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FSTL4-associated genes across cancer lineages are DMC1, PNPLA3, and LRRC59. Each is linked with FSTL4 in more than 3 cancer types. Because this analysis shows association rather than direction, both FSTL4-to-partner and partner-to-FSTL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DMC1 grouped by FSTL4-low versus FSTL4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FSTL4→partner) and Y-score (partner→FSTL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	DMC1 →	+0.347	+3.210	.003	.009	3	3
COAD	PNPLA3 →	+0.755	+2.598	.003	.006	3	3
UCEC	LRRC59 →	+0.562	+2.061	<.001	<.001	3	3
UCEC	ICMT →	+0.485	+2.072	<.001	<.001	3	3
COAD	EIF5A →	+0.607	+3.335	<.001	.005	3	3
COAD	RNF145 →	+0.576	+2.598	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,938 associations by consensus.

DMC1 by FSTL4 expression — COAD

Explore this box plot interactively →