FSTL4

Across TCGA patient cohorts, FSTL4 mutation is significantly associated with the total protein of many other genes, with 54 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FSTL4-associated genes across cancer lineages are EGFR_pY1068, eIF4E, and A-Raf_pS299. Each is linked with FSTL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both FSTL4-to-partner and partner-to-FSTL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by FSTL4-low versus FSTL4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FSTL4→partner) and Y-score (partner→FSTL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.246	-1.584	.003	.009	3	2
UCEC	eIF4E →	+0.164	+1.874	.020	.002	3	2
UCEC	A-Raf_pS299 →	-0.159	-2.584	<.001	.001	3	2
UCEC	FoxM1 →	+0.207	+1.584	.017	.009	3	2
COAD	ACVRL1 →	-0.259	-2.313	.021	.035	3	2
UCEC	MEK1 →	+0.357	+2.584	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 54 associations by consensus.

EGFR_pY1068 by FSTL4 expression — UCEC

Explore this box plot interactively →