FSTL4

Across TCGA cell cohorts, FSTL4 mutation is significantly associated with the RNA expression of many other genes, with 88 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FSTL4-associated genes across cancer lineages are OR14A2, MAPK3, and CD4. Each is linked with FSTL4 in more than 1 cancer types. Because this analysis shows association rather than direction, both FSTL4-to-partner and partner-to-FSTL4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR14A2 grouped by FSTL4-low versus FSTL4-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FSTL4→partner) and Y-score (partner→FSTL4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	OR14A2 →	+0.022	+5.060	<.001	.001	3	2
LARGE_INTESTINE	MAPK3 →	-0.720	-3.541	.004	.001	3	1
LARGE_INTESTINE	CD4 →	+0.607	+2.502	.004	.005	3	1
LARGE_INTESTINE	KRR1 →	+0.863	+3.169	.001	.006	3	1
LARGE_INTESTINE	TAF12 →	+0.492	+3.714	.002	<.001	3	1
LARGE_INTESTINE	HVCN1 →	+0.595	+3.192	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 88 associations by consensus.

OR14A2 by FSTL4 expression — BLOOD_Leukemia

Explore this box plot interactively →