FSTL1

Across TCGA pan-cancer cohorts, FSTL1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated FSTL1 data layer compared with 25 for mass-spec protein and 7 for mass-spec protein.

The strongest signal is observed in brain lower grade glioma (LGG), where higher FSTL1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FSTL1 expression acts as an unfavorable survival marker.

LGG, UCEC, and LUSC are the cancer types where FSTL1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	OS	Median	All	0.173	0.799	<.001	6	view →
UCEC	OS	Median	IV	0.231	0.592	.036	6	view →
LUSC	DFS	Median	II,III,IV	0.135	0.663	.015	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

FSTL1–LGG (OS)

Open the LGG breakdown →