FSTL1

Across TCGA patient cohorts, FSTL1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FSTL1-associated genes across cancer lineages are ASNS, C-Raf, and 14-3-3_beta. Each is linked with FSTL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both FSTL1-to-partner and partner-to-FSTL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by FSTL1-low versus FSTL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FSTL1→partner) and Y-score (partner→FSTL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.417	+1.700	.006	.044	3	3
UCEC	C-Raf →	+0.140	+2.906	.021	.001	3	2
UCEC	14-3-3_beta →	-0.112	-1.687	.008	.044	3	1
UCEC	EGFR →	-0.177	-3.321	.009	.010	3	1
UCEC	eIF4G →	+0.273	+2.222	.038	.011	3	1
UCEC	ERK2 →	+0.163	+2.222	.046	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

ASNS by FSTL1 expression — UCEC

Explore this box plot interactively →