FSD2

mutation — cross-omics
Cross-omicsMUTATION → PROTEIN-RPPAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, FSD2 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FSD2-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, EGFR_pY1068, and FoxM1. Each is linked with FSD2 in more than 3 cancer types. Because this analysis shows association rather than direction, both FSD2-to-partner and partner-to-FSD2 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FSD2→partner) and Y-score (partner→FSD2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
SKCMAcetyl-a-Tubulin-Lys40 →+0.739+2.459.002.01834
UCECEGFR_pY1068 →-0.209-1.137.008.04132
UCECFoxM1 →+0.222+2.009.006.00532
UCECJNK_pT183_Y185 →-0.114-1.124.031.04132
UCECMEK1 →+0.474+3.169<.001<.00132
UCECNotch1 →+0.176+2.432<.001<.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

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