FSD1

Across TCGA patient cohorts, FSD1 mutation is significantly associated with the RNA expression of many other genes, with 2,248 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FSD1-associated genes across cancer lineages are PIMREG, LSS, and FEN1. Each is linked with FSD1 in more than 3 cancer types. Because this analysis shows association rather than direction, both FSD1-to-partner and partner-to-FSD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIMREG grouped by FSD1-low versus FSD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FSD1→partner) and Y-score (partner→FSD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PIMREG →	+0.708	+2.906	.001	.001	3	4
LUAD	LSS →	+0.676	+3.494	.001	.002	3	3
UCEC	FEN1 →	+0.651	+3.711	<.001	<.001	3	3
UCEC	KIF4A →	+0.692	+2.671	<.001	<.001	3	3
UCEC	CDC45 →	+0.756	+1.992	<.001	<.001	3	3
LUAD	NADK →	+0.488	+3.366	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,248 associations by consensus.

PIMREG by FSD1 expression — UCEC

Explore this box plot interactively →