FSCN1

Across TCGA pan-cancer cohorts, FSCN1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FSCN1 data layer compared with 28 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher FSCN1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated FSCN1 expression acts as an unfavorable survival marker, although some lineages such as HNSC show a favorable association.

PDAC, LUAD, and GBM are the cancer types where FSCN1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.269	0.547	<.001	84	view →
LUAD	OS	Median	III,IV	0.216	0.619	.014	16	view →
GBM	OS	Median	All	0.373	0.641	.026	5	view →
LSCC	OS	Quartile	All	0.841	0.963	.036	5	view →
HNSC	OS	Quartile	II,III,IV	0.951	0.802	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FSCN1–PDAC (DFS)

Open the PDAC breakdown →