FSCN1

Across TCGA cell cohorts, FSCN1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible FSCN1-associated genes across cancer lineages are PCDH11Y, CCR8, and CYLC1. Each is linked with FSCN1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FSCN1-to-partner and partner-to-FSCN1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCDH11Y grouped by FSCN1-low versus FSCN1-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FSCN1→partner) and Y-score (partner→FSCN1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	PCDH11Y →	+0.016	+5.087	<.001	.004	3	1
SOFT_TISSUE	CCR8 →	+0.022	+5.369	<.001	.004	3	1
SOFT_TISSUE	CYLC1 →	+0.029	+4.930	<.001	.008	3	1
LARGE_INTESTINE	ELOA3P →	+0.100	+3.819	.001	.003	3	1
LARGE_INTESTINE	SPEM3 →	+0.013	+3.347	<.001	.005	3	1
LARGE_INTESTINE	NEXMIF →	+0.264	+3.196	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

PCDH11Y by FSCN1 expression — URINARY_TRACT

Explore this box plot interactively →