Across TCGA patient cohorts, FSCB mutation is significantly associated with the RNA expression of many other genes, with 6,870 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FSCB-associated genes across cancer lineages are C2orf49, POLE2, and GINS1. Each is linked with FSCB in more than 4 cancer types. Because this analysis shows association rather than direction, both FSCB-to-partner and partner-to-FSCB results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FSCB→partner) and Y-score (partner→FSCB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	C2orf49 →	+0.282	+1.877	<.001	.001	3	5
UCEC	POLE2 →	+0.560	+1.828	<.001	<.001	3	4
UCEC	GINS1 →	+0.576	+1.321	<.001	.002	3	4
UCEC	RAD51AP1 →	+0.628	+1.649	<.001	<.001	3	4
UCEC	FANCE →	+0.475	+4.108	<.001	<.001	3	4
UCEC	CENPA →	+0.461	+2.016	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,870 associations by consensus.

Exploration

FSCB survival (RNA) · tumor vs normal (RNA) · all FSCB data types