FSBP

Across TCGA pan-cancer cohorts, FSBP mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated FSBP data layer compared with 16 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in glioblastoma multiforme (GBM), where higher FSBP mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FSBP expression acts as an unfavorable survival marker, although some lineages such as GBM and LSCC show a favorable association.

GBM, LSCC, and UCEC are the cancer types where FSBP mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
GBM	DFS	Median	All	0.865	0.545	.001	17	view →
LSCC	OS	Median	II,III,IV	0.944	0.502	.001	14	view →
UCEC	DFS	Tertile	All	0.974	0.829	.022	2	view →
PDAC	OS	Tertile	All	0.364	0.737	.039	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

FSBP–GBM (DFS)

Open the GBM breakdown →