FRYL

Across TCGA pan-cancer cohorts, FRYL mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FRYL data layer compared with 29 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher FRYL mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FRYL expression acts as an unfavorable survival marker, although some lineages such as COAD and HNSC show a favorable association.

COAD, HNSC, and LUAD are the cancer types where FRYL mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Tertile	All	1.000	0.898	.023	30	view →
HNSC	DFS	Median	IV	0.862	0.520	<.001	28	view →
LUAD	OS	Tertile	II,III,IV	0.461	0.833	.013	12	view →
UCEC	OS	Tertile	III,IV	1.000	0.322	.042	8	view →
PDAC	DFS	Median	All	0.336	0.482	.019	4	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FRYL–COAD (DFS)

Open the COAD breakdown →