FRYL

Across TCGA patient cohorts, FRYL mutation is significantly associated with the RNA expression of many other genes, with 5,194 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRYL-associated genes across cancer lineages are RANBP1, MCM5, and UQCRC1. Each is linked with FRYL in more than 4 cancer types. Because this analysis shows association rather than direction, both FRYL-to-partner and partner-to-FRYL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RANBP1 grouped by FRYL-low versus FRYL-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRYL→partner) and Y-score (partner→FRYL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RANBP1 →	+0.656	+3.459	<.001	.005	3	5
UCEC	MCM5 →	+0.415	+1.300	<.001	<.001	3	4
UCEC	UQCRC1 →	+0.276	+1.353	.001	<.001	3	4
BLCA	GRPEL1 →	+0.500	+3.364	<.001	.004	3	4
UCEC	NCAPG →	+0.611	+1.415	<.001	<.001	3	4
UCEC	MCM3 →	+0.326	+1.573	.005	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,194 associations by consensus.

RANBP1 by FRYL expression — LUAD

Explore this box plot interactively →