FRYL

Across TCGA patient cohorts, FRYL mutation is significantly associated with the total protein of many other genes, with 81 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRYL-associated genes across cancer lineages are Cyclin-B1, FASN, and INPP4B. Each is linked with FRYL in more than 3 cancer types. Because this analysis shows association rather than direction, both FRYL-to-partner and partner-to-FRYL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by FRYL-low versus FRYL-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRYL→partner) and Y-score (partner→FRYL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.576	+1.700	<.001	<.001	3	4
LUSC	FASN →	+0.478	+2.331	.016	.019	3	3
COAD	INPP4B →	-0.226	-1.678	.039	.020	3	3
COAD	Caspase-7-cleavedD198 →	+0.715	+1.230	.002	.022	3	3
UCEC	4E-BP1 →	+0.234	+1.614	<.001	.002	3	3
UCEC	Cyclin-E2 →	+0.109	+0.874	.011	.036	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 81 associations by consensus.

Cyclin-B1 by FRYL expression — UCEC

Explore this box plot interactively →