FRYL

Across TCGA cell cohorts, FRYL mutation is significantly associated with the RNA expression of many other genes, with 791 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FRYL-associated genes across cancer lineages are OR10T2, OXT, and ASB11. Each is linked with FRYL in more than 1 cancer types. Because this analysis shows association rather than direction, both FRYL-to-partner and partner-to-FRYL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10T2 grouped by FRYL-low versus FRYL-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRYL→partner) and Y-score (partner→FRYL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	OR10T2 →	+0.179	+2.874	<.001	.007	3	2
URINARY_TRACT	OXT →	+0.030	+2.722	<.001	.007	3	2
BLOOD_Lymphoma	ASB11 →	+0.023	+2.765	.003	.007	3	2
BLOOD_Lymphoma	H3-4 →	+0.129	+3.722	.008	.002	3	2
LUNG_NSCLC_LUSC	PRAMEF14 →	+0.090	+4.643	<.001	.008	3	2
LUNG_NSCLC_LUSC	GSTT4 →	+0.013	+4.643	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 791 associations by consensus.

OR10T2 by FRYL expression — LUNG_SCLC

Explore this box plot interactively →