FRY

Across TCGA pan-cancer cohorts, FRY Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated FRY data layer compared with 25 for mass-spec protein and 5 for mass-spec protein.

The strongest signal is observed in rectum adenocarcinoma (READ), where higher FRY Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated FRY expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

READ, UCEC, and HNSC are the cancer types where FRY Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
READ	OS	Median	All	0.198	0.829	.001	24	view →
UCEC	DFS	Median	All	0.900	0.600	.002	24	view →
HNSC	OS	Median	III,IV	0.341	0.637	.003	24	view →
THCA	DFS	Median	All	0.063	0.811	<.001	15	view →
LUSC	DFS	Median	II,III,IV	0.333	0.689	.017	13	view →
LUAD	DFS	Median	IV	0.109	0.714	.001	12	view →
BLCA	DFS	Median	All	0.796	0.301	.028	6	view →
SARC	DFS	Median	All	0.121	0.591	.042	3	view →
LGG	DFS	Median	All	0.430	0.828	.029	1	view →
STAD	OS	Median	II,III,IV	0.841	0.659	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

FRY–READ (OS)

Open the READ breakdown →