FRY

Across TCGA pan-cancer cohorts, FRY mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated FRY data layer compared with 25 for mass-spec protein and 10 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher FRY mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated FRY expression acts as an unfavorable survival marker, although some lineages such as PDAC and GBM show a favorable association.

PDAC, LUAD, and GBM are the cancer types where FRY mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	All	0.849	0.652	.001	45	view →
LUAD	DFS	Median	All	0.831	0.967	.007	39	view →
GBM	DFS	Quartile	All	0.489	0.217	.014	5	view →
UCEC	OS	Tertile	All	0.878	1.000	.042	4	view →
CCRCC	DFS	Quartile	All	0.937	0.613	.034	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

FRY–PDAC (DFS)

Open the PDAC breakdown →