FRY

Across TCGA patient cohorts, FRY mutation is significantly associated with the RNA expression of many other genes, with 8,107 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRY-associated genes across cancer lineages are PGAM5, FCER1A, and ERH. Each is linked with FRY in more than 5 cancer types. Because this analysis shows association rather than direction, both FRY-to-partner and partner-to-FRY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PGAM5 grouped by FRY-low versus FRY-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRY→partner) and Y-score (partner→FRY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PGAM5 →	+0.446	+1.584	<.001	<.001	3	6
LUAD	FCER1A →	-1.302	-2.075	.001	.006	3	6
STAD	ERH →	+0.336	+2.016	.003	.001	3	6
LUAD	BUB1B →	+0.902	+2.584	<.001	.001	3	5
UCEC	NAE1 →	+0.459	+1.295	<.001	<.001	3	5
UCEC	CENPN →	+0.721	+2.045	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,107 associations by consensus.

PGAM5 by FRY expression — UCEC

Explore this box plot interactively →