FRY

Across TCGA patient cohorts, FRY mutation is significantly associated with the total protein of many other genes, with 86 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRY-associated genes across cancer lineages are PCNA, Cyclin-B1, and eEF2. Each is linked with FRY in more than 6 cancer types. Because this analysis shows association rather than direction, both FRY-to-partner and partner-to-FRY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by FRY-low versus FRY-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRY→partner) and Y-score (partner→FRY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PCNA →	+0.301	+2.700	<.001	.006	3	7
UCEC	Cyclin-B1 →	+0.632	+1.647	<.001	<.001	3	6
STAD	eEF2 →	+0.212	+1.999	.048	.009	3	5
BRCA	GAPDH →	+0.997	+3.169	.002	.020	3	5
BRCA	c-Kit →	-0.545	-2.994	.049	.037	3	5
COAD	ASNS →	+0.516	+2.169	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 86 associations by consensus.

PCNA by FRY expression — LUAD

Explore this box plot interactively →