FRS3

Across TCGA patient cohorts, FRS3 mutation is significantly associated with the RNA expression of many other genes, with 1,005 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRS3-associated genes across cancer lineages are RNU4-79P, RN7SL237P, and SAR1B. Each is linked with FRS3 in more than 2 cancer types. Because this analysis shows association rather than direction, both FRS3-to-partner and partner-to-FRS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-79P grouped by FRS3-low versus FRS3-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRS3→partner) and Y-score (partner→FRS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	RNU4-79P →	+0.381	+5.155	<.001	.002	3	3
LIHC	RN7SL237P →	+0.125	+5.447	.001	.005	3	2
UCEC	SAR1B →	+0.503	+3.931	<.001	<.001	3	2
UCEC	EME1 →	+0.505	+1.936	.004	.003	3	2
UCEC	CXCL13 →	+1.615	+1.925	<.001	.005	3	2
UCEC	C12orf43 →	+0.258	+1.936	.005	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,005 associations by consensus.

RNU4-79P by FRS3 expression — LUAD

Explore this box plot interactively →