FRS3

Across TCGA patient cohorts, FRS3 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRS3-associated genes across cancer lineages are Rad50, Lck, and 14-3-3_beta. Each is linked with FRS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FRS3-to-partner and partner-to-FRS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by FRS3-low versus FRS3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRS3→partner) and Y-score (partner→FRS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.225	-2.000	.018	.010	3	2
COAD	Lck →	+0.467	+2.832	.005	.035	3	1
UCEC	14-3-3_beta →	-0.099	-3.295	.011	.009	3	1
UCEC	eEF2 →	+0.373	+2.000	.007	.010	3	1
UCEC	eIF4E →	+0.177	+2.000	.032	.010	3	1
UCEC	ERK2 →	+0.264	+3.459	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

Rad50 by FRS3 expression — UCEC

Explore this box plot interactively →