FRS3

Across TCGA cell cohorts, FRS3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,624 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FRS3-associated GO terms across cancer lineages are Negative regulation of DNA-templated transcription initiation, Negative regulation of transcription initiation by RNA polymerase II, and Regulation of DNA-templated transcription initiation. Each is linked with FRS3 in more than 13 cancer types. Because this analysis shows association rather than direction, both FRS3-to-partner and partner-to-FRS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of DNA-templated transcription initiation grouped by FRS3-low versus FRS3-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FRS3→partner) and Y-score (partner→FRS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Negative regulation of DNA-templated transcription initiation →	+0.110	+0.591	<.001	<.001	3	14
LARGE_INTESTINE	Negative regulation of transcription initiation by RNA polymerase II →	+0.110	+0.591	<.001	<.001	3	14
URINARY_TRACT	Regulation of DNA-templated transcription initiation →	+0.052	+0.585	.003	.004	3	13
KIDNEY	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.124	+0.692	.002	<.001	2	14
BONE	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.201	+0.805	<.001	.001	3	12
OESOPHAGUS	Negative regulation of myoblast fusion →	+0.170	+0.861	<.001	.001	1	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,624 associations by consensus.

Negative regulation of DNA-templated transcription initiation by FRS3 expression — LARGE_INTESTINE

Explore this box plot interactively →