FRS3

Across TCGA cell cohorts, FRS3 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible FRS3-associated genes across cancer lineages are MRGPRG, C18orf63, and SELENOV. Each is linked with FRS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both FRS3-to-partner and partner-to-FRS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRGPRG grouped by FRS3-low versus FRS3-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRS3→partner) and Y-score (partner→FRS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	MRGPRG →	+0.080	+2.865	.002	.004	3	2
BLOOD_Myeloma	C18orf63 →	+0.013	+4.807	<.001	.006	3	1
BLOOD_Leukemia	SELENOV →	+0.062	+3.339	.002	.006	3	1
BLOOD_Leukemia	DPRX →	+0.076	+3.475	<.001	.006	3	1
BLOOD_Leukemia	TSSK1B →	+0.009	+3.289	<.001	.009	3	1
BLOOD_Leukemia	TEX48 →	+0.030	+3.475	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

MRGPRG by FRS3 expression — OVARY

Explore this box plot interactively →