FRS2

Across TCGA patient cohorts, FRS2 protein abundance is significantly associated with the RNA expression of many other genes, with 4,017 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible FRS2-associated genes across cancer lineages are ADGRG5, PEX7, and BCAS4. Each is linked with FRS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both FRS2-to-partner and partner-to-FRS2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FRS2 versus ADGRG5 in LSCC, with a Pearson correlation of -0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRS2→partner) and Y-score (partner→FRS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ADGRG5 →	-0.691	-0.242	.001	<.001	3	3
BRCA	PEX7 →	+0.675	+0.418	<.001	<.001	3	2
BRCA	BCAS4 →	+0.906	+0.422	<.001	<.001	3	2
BRCA	G6PC3 →	+0.646	+0.343	<.001	.003	3	2
UCEC	LIPG →	-1.230	-0.401	<.001	<.001	3	2
BRCA	THSD4 →	+1.995	+0.435	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,017 associations by consensus.

FRS2 vs ADGRG5 — LSCC

Explore this scatter interactively →