FRS2

Across TCGA patient cohorts, FRS2 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRS2-associated genes across cancer lineages are FoxM1, MEK1, and mTOR_pS2448. Each is linked with FRS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FRS2-to-partner and partner-to-FRS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by FRS2-low versus FRS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRS2→partner) and Y-score (partner→FRS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.238	+1.765	.014	.014	3	2
UCEC	MEK1 →	+0.431	+2.169	.001	.003	3	2
UCEC	mTOR_pS2448 →	-0.125	-2.308	.025	.033	3	2
UCEC	VEGFR2 →	+0.357	+2.676	.001	<.001	3	2
UCEC	Caspase-7-cleavedD198 →	+0.721	+2.584	.001	.010	3	2
UCEC	C-Raf →	+0.234	+1.765	<.001	.014	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

FoxM1 by FRS2 expression — UCEC

Explore this box plot interactively →