FRS2

Across TCGA cell cohorts, FRS2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,316 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible FRS2-associated GO terms across cancer lineages are Golgi vesicle transport, Golgi organization, and Post-Golgi vesicle-mediated transport. Each is linked with FRS2 in more than 14 cancer types. Because this analysis shows association rather than direction, both FRS2-to-partner and partner-to-FRS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Golgi vesicle transport grouped by FRS2-low versus FRS2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (FRS2→partner) and Y-score (partner→FRS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Golgi vesicle transport →	+0.079	+1.310	<.001	<.001	3	15
STOMACH	Golgi organization →	+0.084	+0.835	<.001	.003	2	14
OVARY	Post-Golgi vesicle-mediated transport →	+0.065	+0.906	<.001	<.001	3	13
STOMACH	Macroautophagy →	+0.072	+0.782	<.001	.001	3	13
STOMACH	Positive regulation of TORC2 signaling →	+0.116	+0.809	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Negative regulation of gene expression, epigenetic →	+0.061	+1.245	.001	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,316 associations by consensus.

Golgi vesicle transport by FRS2 expression — BREAST

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