FRS2

Across TCGA cell cohorts, FRS2 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. STOMACH shows the largest number of these associations.

The most reproducible FRS2-associated genes across cancer lineages are CRYGD, MMP26, and FIGLA. Each is linked with FRS2 in more than 1 cancer types. Because this analysis shows association rather than direction, both FRS2-to-partner and partner-to-FRS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CRYGD grouped by FRS2-low versus FRS2-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRS2→partner) and Y-score (partner→FRS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	CRYGD →	+0.229	+5.285	<.001	.003	3	1
STOMACH	MMP26 →	+0.673	+5.285	<.001	.003	3	1
STOMACH	FIGLA →	+0.253	+5.285	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

CRYGD by FRS2 expression — STOMACH

Explore this box plot interactively →