FRRS1

Across TCGA patient cohorts, FRRS1 mutation is significantly associated with the total protein of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRRS1-associated genes across cancer lineages are ATM, mTOR, and Shc_pY317. Each is linked with FRRS1 in more than 1 cancer types. Because this analysis shows association rather than direction, both FRRS1-to-partner and partner-to-FRRS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by FRRS1-low versus FRRS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRRS1→partner) and Y-score (partner→FRRS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.553	-3.321	.019	.010	3	2
UCEC	mTOR →	-0.226	-3.321	.007	.010	3	1
UCEC	Shc_pY317 →	-0.163	-3.000	.041	.036	3	1
UCEC	STAT5a →	+0.523	+3.000	.012	.036	2	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

ATM by FRRS1 expression — UCEC

Explore this box plot interactively →