FRMPD4

Across TCGA patient cohorts, FRMPD4 mutation is significantly associated with the total protein of many other genes, with 85 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRMPD4-associated genes across cancer lineages are Caspase-7-cleavedD198, cIAP, and JNK_pT183_Y185. Each is linked with FRMPD4 in more than 3 cancer types. Because this analysis shows association rather than direction, both FRMPD4-to-partner and partner-to-FRMPD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by FRMPD4-low versus FRMPD4-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRMPD4→partner) and Y-score (partner→FRMPD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+0.957	+2.016	<.001	.015	3	4
UCEC	cIAP →	+0.087	+1.178	.008	.001	3	4
UCEC	JNK_pT183_Y185 →	-0.142	-1.584	<.001	.001	3	3
BRCA	EGFR →	-0.243	-2.321	.035	.037	3	3
UCEC	mTOR_pS2448 →	-0.108	-1.630	.002	.002	3	3
UCEC	PCNA →	+0.207	+2.201	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 85 associations by consensus.

Caspase-7-cleavedD198 by FRMPD4 expression — COAD

Explore this box plot interactively →