FRMPD3

Across TCGA pan-cancer cohorts, FRMPD3 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated FRMPD3 data layer compared with 9 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher FRMPD3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated FRMPD3 expression acts as an unfavorable survival marker, although some lineages such as SKCM and LGG show a favorable association.

UVM, KIRP, and SKCM are the cancer types where FRMPD3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Tertile	II,III,IV	0.396	0.808	<.001	117	view →
KIRP	OS	Tertile	All	0.341	0.788	<.001	63	view →
SKCM	OS	Quartile	All	0.462	0.258	<.001	55	view →
KIRC	DFS	Quartile	All	0.689	0.857	<.001	52	view →
UCEC	DFS	Tertile	All	0.776	0.884	.001	52	view →
LGG	OS	Median	All	0.937	0.851	<.001	39	view →
BRCA	DFS	Tertile	IV	0.894	0.352	.001	30	view →
CHOL	DFS	Tertile	All	0.745	0.159	.005	27	view →
THYM	OS	Tertile	All	0.707	0.954	.014	24	view →
LUSC	DFS	Median	III,IV	0.407	0.883	.006	18	view →
SARC	OS	Median	All	0.839	0.608	<.001	17	view →
STAD	OS	Tertile	IV	0.744	0.294	.006	15	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

FRMPD3–UVM (OS)

Open the UVM breakdown →