Across TCGA pan-cancer cohorts, FRMPD3-AS1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of FRMPD3-AS1’s most consistent transcriptional readouts.
The strongest signal is observed in breast invasive carcinoma (BRCA), where FRMPD3-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types FRMPD3-AS1 is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
BRCA and THCA are the cancer types where FRMPD3-AS1 tumor–normal differential expression is most reproducible.