FRMPD1

Across TCGA patient cohorts, FRMPD1 mutation is significantly associated with the total protein of many other genes, with 83 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRMPD1-associated genes across cancer lineages are 4E-BP1, ASNS, and Cyclin-B1. Each is linked with FRMPD1 in more than 4 cancer types. Because this analysis shows association rather than direction, both FRMPD1-to-partner and partner-to-FRMPD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by FRMPD1-low versus FRMPD1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRMPD1→partner) and Y-score (partner→FRMPD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.324	+1.547	<.001	<.001	3	5
STAD	ASNS →	+0.486	+2.584	.008	.010	3	4
UCEC	Cyclin-B1 →	+0.672	+1.862	<.001	<.001	3	4
BLCA	Akt_pT308 →	+0.357	+2.182	.001	.033	3	3
BLCA	Rictor →	-0.689	-2.115	.047	.018	3	3
STAD	Caspase-7-cleavedD198 →	+1.122	+2.584	<.001	.010	1	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 83 associations by consensus.

4E-BP1 by FRMPD1 expression — UCEC

Explore this box plot interactively →