FRMD8

Across TCGA patient cohorts, FRMD8 protein abundance is significantly associated with the RNA expression of many other genes, with 10,395 significant associations in total. GBM shows the largest number of these associations.

The most reproducible FRMD8-associated genes across cancer lineages are MCM4, RAD51AP1, and STMN1. Each is linked with FRMD8 in more than 4 cancer types. Because this analysis shows association rather than direction, both FRMD8-to-partner and partner-to-FRMD8 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, FRMD8 versus MCM4 in GBM, with a Pearson correlation of -0.45.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRMD8→partner) and Y-score (partner→FRMD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MCM4 →	-0.531	-0.224	<.001	<.001	3	4
GBM	RAD51AP1 →	-0.797	-0.350	<.001	<.001	3	4
GBM	STMN1 →	-0.860	-0.300	<.001	<.001	3	4
LSCC	TMPO →	-0.570	-0.187	.002	.002	3	4
LUAD	MCM8 →	-0.586	-0.192	.001	.001	3	4
LSCC	HTR7 →	+0.845	+0.165	.002	.004	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,395 associations by consensus.

FRMD8 vs MCM4 — GBM

Explore this scatter interactively →