FRMD8

Across TCGA patient cohorts, FRMD8 mutation is significantly associated with the total protein of many other genes, with 21 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible FRMD8-associated genes across cancer lineages are JNK_pT183_Y185, Ku80, and N-Ras. Each is linked with FRMD8 in more than 1 cancer types. Because this analysis shows association rather than direction, both FRMD8-to-partner and partner-to-FRMD8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by FRMD8-low versus FRMD8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (FRMD8→partner) and Y-score (partner→FRMD8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.169	-2.687	.026	.006	3	1
UCEC	Ku80 →	+0.296	+2.013	.005	.018	3	1
UCEC	N-Ras →	-0.122	-1.986	.022	.032	3	1
UCEC	p62 Lck ligand →	+0.433	+3.469	.003	.002	3	1
UCEC	P-Cadherin →	-0.164	-2.999	.011	.035	3	1
UCEC	Rad50 →	-0.312	-3.308	.004	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

JNK_pT183_Y185 by FRMD8 expression — UCEC

Explore this box plot interactively →